Valproic acid (VPA) is widely used for the treatment of epilepsy, migraine, and a variety of psychiatric conditions
Valproic acid, a broad-spectrum anticonvulsant drug, commonly causes elevated ammonia levels, which is usually asymptomatic in most cases
Although acute VPA intoxication frequently results in mild, self Objective: To report a case of hyperammonemia associated with the interaction between topiramate and valproic acid
This enzymatic inhibition is why serum ammonia concentrations can elevate in valproic acid toxicity
Valproic acid-induced hyperammonemia: incidence Valproic acid can cause high levels of ammonia in your blood, which is known as hyperammonemia
It can be life-threatening and requires immediate medical treatment
The reported prevalence of valproic acid induced hyperammonemia is as high as 35–45% and seems to be higher in patients with
5 equivalent of sodium hydroxide
Valproic acid use has been associated with the induction of hyperammonemic encephalopathy through astrocytic edema, renal
Abstract
Upon an increase in blood ammonia levels, glutamine synthetase converts glutamate and ammonia to glutamine
In some people, hyperammonemia may be clinically significant, resulting in hyperammonemic encephalopathy, which may be severe