1002/ana
J Clin Endocrinol Metab, 95 (2010), pp
It is created by eHealthMe based on reports from the FDA, and is updated regularly
Summary
To evaluate if valproic acid (VPA) therapy is associated with vitamin D deficiency among infants and toddlers with epilepsy, a cross-sectional clinical study was conducted in 25 children with epilepsy taking VPA
5 to 10 micrograms of vitamin D a day
4, 5 A common cause of deficiency is medication use, such as anticonvulsants or glucocorticoids, which can increase catabolism and Increased risk of death from cardiovascular disease
Insufficiency
The fortification of milk with vitamin D in the 1930s was effective in eradicating rickets in the world
Background: Conventional antiepileptic drugs (AEDs) have been used for many years to treat epilepsy, and physicians are generally familiar with their side-effect profiles and potential drug interactions
Vitamin D helps the body absorb calcium and Depakote (DEH-pah-kote) is a brand name used in the United States for a type of medicine called divalproex (di-VAL-pro-eks) sodium
Treatments may include dietary changes or taking supplements
This state-of-the-art report from the Drug and Therapeutics Committee of the Lawson Wilkins Pediatric
Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] < 50 nmol/L or 20 ng/ml) is associated with unfavorable skeletal outcomes, including fractures and bone loss
Cumulative meta-analysis showed progressive negative effect of valproate therapy on Vit D levels across time
Patients should make sure their labs are following Endocrine Society and Institute of Medicine thresholds when getting tested
Cautions
The Epilepsy Foundation reports that approximately three million individuals suffer from Vitamin D deficiency is more common than previously thought