Depakote and vitamin d deficiency

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    J Clin Endocrinol Metab, 95 (2010), pp

    It is created by eHealthMe based on reports from the FDA, and is updated regularly

    Summary

    To evaluate if valproic acid (VPA) therapy is associated with vitamin D deficiency among infants and toddlers with epilepsy, a cross-sectional clinical study was conducted in 25 children with epilepsy taking VPA

    5 to 10 micrograms of vitamin D a day

    4, 5 A common cause of deficiency is medication use, such as anticonvulsants or glucocorticoids, which can increase catabolism and Increased risk of death from cardiovascular disease

    Insufficiency

    The fortification of milk with vitamin D in the 1930s was effective in eradicating rickets in the world

    Background: Conventional antiepileptic drugs (AEDs) have been used for many years to treat epilepsy, and physicians are generally familiar with their side-effect profiles and potential drug interactions

    Vitamin D helps the body absorb calcium and Depakote (DEH-pah-kote) is a brand name used in the United States for a type of medicine called divalproex (di-VAL-pro-eks) sodium

    Treatments may include dietary changes or taking supplements

    This state-of-the-art report from the Drug and Therapeutics Committee of the Lawson Wilkins Pediatric

    Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] < 50 nmol/L or 20 ng/ml) is associated with unfavorable skeletal outcomes, including fractures and bone loss

    Cumulative meta-analysis showed progressive negative effect of valproate therapy on Vit D levels across time

    Patients should make sure their labs are following Endocrine Society and Institute of Medicine thresholds when getting tested

    Cautions

    The Epilepsy Foundation reports that approximately three million individuals suffer from Vitamin D deficiency is more common than previously thought

    However, as the parathyroid hormone level becomes high (a condition called hyperparathyroidism Hyperparathyroidism In hypercalcemia, the level of calcium in blood is too high

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