ROUTE
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The exact mechanism in the relief of parkinsonian symptoms remains unelusive; however, it has been believed that antimuscarinic agents
Onset: W/in 1 hr
Rare side effects of trihexyphenidyl have included hallucinations, agitation, confusion, delirium, delusions, and depersonalization
Onset: W/in 1 hr
Generic Name
A muscarinic antagonist that has effects in both the central and peripheral nervous systems
A 75-year-old man with a 10-year history of parkinsonism developed fever and acute delirium after taking levodopa plus trihexyphenidyl [12]
Concomitant Use with Levodopa: 3 to 6 mg orally per day in divided doses
In 1952, beneficial effects of trihexyphenidyl in writer’s cramp and “dystonia musculorum deformans” were first reported [109, 110]
Therapeutic Effects: Diminished signs and symptoms of parkinsonian syndrome (tremors, rigidity)
Trihexyphenidyl can impair memory in elderly people [6]
For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute
It is designated chemically as α-Cyclohexylα-phenyl-1-piperidinepropanol hydrochloride and its structural formula is as follows: Phenothiazines are contraindicated because the toxicity may be intensified due to their antimuscarinic