PURPOSE Nifedipine is commonly prescribed for the treatment of chilblains (pernio, perniosis) on the basis of observational studies and a single small, older clinical trial
Usual Adult Dose for Hypertension
(13) Minoxidil is a vasodilator selective for arterioles rather than for veins, similar to
Pernio (also known as chilblains or perniosis) is a condition characterized by the development of cold-induced erythrocyanotic skin lesions
Kirchhof1,2 Abstract Idiopathic chilblains is a cold- induced inflammatory condition that causes significant morbidity
Br J Dermatol 1989; 120:267–75
To decide the correct dose for you, your doctor will check your blood pressure
17 Patra and colleagues showed that nifedipine was successful for the treatment of pernio with 80 to 90 percent resolution in one to two weeks
The exact reason why this reaction occurs is unknown
Chilblains (also known as pernio) are localized cutaneous inflammatory lesions of the extremities precipitated by cold (dry cold) or high humidity (damp cold)
For example, your heels, lower legs and thighs (especially in horse riders)
How long does nifedipine take to work? Nifedipine starts to work on the day you start taking it, but it may take a couple of weeks to fully take effect
293 (6552); 1986 Oct 11
Chilblains derives from two Old English words "chill" ( cold ) and "blegen" (sore)
A comparison of the pre‐and post‐treatment skin biopsies showed resolution of the dermal oedema and The second-line therapy for chilblains is a calcium channel blocker such as oral nifedipine: a double-blind, placebo-controlled trial found this drug to be efficacious for the treatment of chilblains
Occasionally, it is used to treat the phenomenon of Raynaud and Chilblains
Development of a UV-Stabilized Topical Formulation of Nifedipine for the Treatment of Raynaud Phenomenon and Chilblains Pharmaceutics
A comparison of the pre‐and post‐treatment skin biopsies showed resolution of the dermal oedema and One study found Nifedipine significantly reduced the time it takes to heal chilblains and improved associated symptoms like pain and lesions
which we considered a sufficient dosage to induce local vascular Smits, P
Nifedipine vs placebo for treatment of chronic chilblains: a randomized Chilblains are caused by the vasoconstriction of the deep cutaneous arterioles along with concomitant dilatation of the smaller, superficial vessels
This resulted in a nonsignificant scores per week, not corrected for temperature, in each arm and study phase
Chilblains, also known as perniosis, usually clears up in 2 or 3 weeks, especially if the weather gets warmer