Only use intravenous administration when these options are not feasible and where cardiac monitoring is available
Total phenytoin level: The target total phenytoin level is ~10-20 ug/mL (and ideally 15-20 ug/mL in status epilepticus)
Background
Therapeutic drug monitoring of phenytoin is necessary to ensure dosage delivery is at therapeutic levels
Phenytoin is a hydantoin compound related to the barbiturates that are used for the treatment of seizures
Health & Medicine
Calculates phenytoin loading doses, maintenance dose and correct levels based on serum albumin
Uses Warnings Before taking Dosage Side effects Interactions What is phenytoin? Phenytoin is an anti-epileptic drug, also called an
The results suggest that a measured free phenytoin should be obtained where possible to guide phenytoin dosing
Summarize the interprofessional team's coordinated
Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon)
The following equation is a simple pharmacokinetic equation to estimate a loading dose or resulting serum concentration of a drug
This finding suggests that once daily dosing of phenytoin is reasonable and that the time period to achieve a new serum level after a dosing change may take 2 weeks or more
It may also be used in the prevention of seizures following head trauma, and in ventricular arrhythmias
Therapeutic level 10-20mg/L
The recommended starting dose for adult patients who have received no previous treatment is one 100-mg DILANTIN (extended phenytoin sodium capsule, USP) by mouth three times daily
However, fentanyl exhibits vastly different properties
After another 6 hours the serum phenytoin
The metabolism of phenytoin to the major metabolite, 5-(p-hydroxyphenyl)-5-(phenylhydantoin, is saturable, giving rise to a non linear dose-serum concentration relationship
The rate of intravenous phenytoin administration should not exceed 50 mg/minute in adults and 1 to 3 mg/kg/minute (or 50 mg/minute, whichever is slower) in pediatric patients because of the risk of severe hypotension and cardiac arrhythmias
It is an effective anticonvulsant for the chronic treatment of tonic-clonic (grand mal) or partial seizures and the acute treatment of generalized status epilepticus ( Table 10-1 )
05 ml/kg) IV
Single daily dosage (phenytoin sodium, extended): If seizure control is established with divided doses of three 100-mg extended phenytoin sodium capsules per day, once-a-day dosage with 300 mg PO may be considered
Phenytoin is an antiepileptic drug which can be used in the treatment of epilepsy
[4] Mechanism of Action
There is no caveat included for the caution regarding the use phenytoin or carbamazepine as a second-line agent if a channelopathy is suspected (page 11) and further, for the incorporation of genetic testing in the treatment
Medications are an important part of the management of patients with kidney disease
There is a possibility of