Nifedipine is a drug belonging to a class of pharmacological agents known as the calcium channel blockers
Oral: Extended release: Initial: 30 or 60 mg once daily; increase as needed to effective antianginal dose over 1 to 2 weeks
In addition, each tablet contains the following inactive ingredients: anhydrous lactose, colloidal Amlodipine has a slower onset, longer half-life (30-50 hours) and longer duration of action than nifedipine; Pharmacology 101
Special interests in diagnostic and procedural Pharmacology of Nifedipine G
Because of presystemic metabolism, the bioavailability is about 56% to 77%
2 (PubChem release 2021
Kroneberg 3 Chapter; Abstract
In general, the pharmacokinetic consequences of hyperlipidemia include increased total drug concentrations and decreased unbound fraction in plasma
But, whether this pharmacokinetic drug-drug interaction (DDI) between nifedipine and apatinib could enhance the antihypertensive effect of nifedipine, causing sever changes of blood pressure was unknown
Nifedipine is an inhibitor of L-type voltage gated calcium channels that reduces blood pressure and increases oxygen supply to the heart
Nifedipine is a drug belonging to a class of pharmacological agents known as the calcium channel blockers
Nifediac CC ® Extended-release Tablets
Abstract Nifedipine is almost completely absorbed from the gastrointestinal tract as shown by plasma levels after sublingual, oral, and rectal administration
They are used more
Molecular Formula C17H18N2O6 Synonyms nifedipine 21829-25-4 Adalat Procardia Procardia XL View More Molecular Weight 346
Abstract Purpose Antihypertensive drugs are among the most prescribed drugs during pregnancy
This paper is a brief synopsis of the main pharmacological properties of
4 +/- 1
Methyldopa, labetalol, and nifedipine have been perceived safe to use during pregnancy and are therefore recommended in international guidelines for treatment of hypertension
In addition, nifedipine has a short duration of action, requiring the use of special galenic formulations to allow one dose a day
2
It has a molecular weight of 346
The Nifedipine PBPK model's predictive accuracy was confirmed by non-pregnant and pregnant validation studies
We compared newly developed delayed-release oral tablets (test) of 30-mg nifedipine (NFP) with its marketed counterpart (30 mg; reference) in healthy adult Chinese volunteers to assess the former's bioequivalence
High risk was defined as a medical history significant for arrhythmia, MI, or stroke
Overall, each combination lowered mean systolic and diastolic pressures more than nifedipine alone
8 ± 18
5 mg/kg)
Top 200 drugs
labetalol, nifedipine, pharmacokinetics, pregnancy, and placenta