A left shift of the oxygen saturation curve indicates an increase in the oxygen affinity of hemoglobin, which reduces oxygen availability to the tissues
A rightward shift indicates Fig
Altered blood pH during exercise causes the affinity of hemoglobin to decrease, which is shown as a ___ shift in the oxyhemoglobin dissociation curve
At the same pH of 7
After 6 hours of acidosis, the red cell levels of 2,3 DPG have declined enough to shift the oxygen dissociation curve (ODC) back to normal
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The oxygen dissociation curve can be shifted right or left by a variety of factors
Oxygen is transported in the blood in two ways: Dissolved in the blood (1
(a) A sigmoid curve obtained when percentage saturation of haemogblobin with O 2 is plotted against the p O 2
Introduction
Factors which result in shifting of the oxygen-dissociation curve to the right include increased concentration of pCO2, acidosis, raised temperature and high concentrations of Analyses of data from oxygen dissociation curves (Table 1) show that the p
The oxyhemoglobin dissociation curve (ODC) is a sigmoid curve representing the relationship between arterial hemoglobin saturations (SaO 2) at different arterial blood oxygen tensions (PaO 2) [1,2]; the continuous correlation between SaO 2 and PaO 2 is reported as hemoglobin–oxygen (Hb-O 2) affinity
Oxygen-haemoglobin dissociation curve is used to study the percentage saturation of oxygen to hemoglobin
This leftward shift has also been demonstrated with administration of the CAI benzolamide ()
So, let’s get right into it
An increase in PCO2 b
However, carrying capacity is not changed, and systemic arterial blood at a PO2 of 100 mm Hg is still close to 100% saturation
A study of the effect of induced acidosis and alkalosis on the oxyhemoglobin dissociation curve of normal man was therefore carried out, and