5 mg/kg (5 mg/kg base) per day, whichever is lower, as the incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded Jan 1, 2001 · If azathioprine is to be discontinued after long-term use, it is probably best to taper the dosage rather than discontinue abruptly as a rebound increase immune response can result
At first, 3 to 5 milligrams (mg) per
Medically reviewed by Drugs
Abstract
The risk for hematopoietic toxicity can more than double Chung's group noted that the "normal" cell counts physicians use for decisions on azathioprine
If you miss a dose while on a once daily schedule, skip the dose that was missed and
In addition, it recommended routine TPMT testing prior to embarking on azathioprine therapy
Medscape - CMV dosing for Cytovene, (ganciclovir), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information
Azathioprine is chemically 6-[(1-methyl-4-nitro-1 H-imidazol
Medscape - Gout dosing for Uloric (febuxostat), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information
5 to 1 mg per pound of body weight given orally once a day
The British Society of Gastroenterology advises the following dosing schedule based on TPMT: Normal TPMT = 2mg/kg A downward trend of FBC and neutrophil count or an upward trend in liver transaminases could be a sign of toxicity, even if the absolute levels are normal
Your doctor will tell you how much to take
PO (with azathioprine or MMF): 0
IMURAN (azathioprine), an immunosuppressive antimetabolite, is available in tablet form for oral administration
It has also frequently been used in other skin diseases as a means of reducing oral steroid use
Azathioprine frequently is used with corticosteroids (prednisolone), with the goal of reducing the dose of both drugs and moving towards alternate day therapy
It has been used as an immunosuppressive agent for the treatment of a variety of disorders; these include a
Prior to starting azathioprine therapy, the patient’s thiopurine methyltransferase (TPMT) genotype was found to be TPMT*1/TMPT*1, which is considered normal enzyme activity
The dosing of azathioprine, including potential testing for thiopurine S-methyltransferase (TPMT) deficiency, and monitoring for adverse effects are described separately