There are 249 drugs known to interact with clopidogrel, along with 3 disease interactions
The strongest evidence for an interaction exists for omeprazole and lansoprazole
Does Plavix interact with prednisone? No, there aren’t any known interactions between Plavix and prednisone
The interaction between omeprazole and clopidogrel is considered vigorous due to the inhibitory effect of PPI on CYP2C19 isoenzyme [20,21]
The dosage of clopidogrel does not need adjusting in people with liver disease
Drug-Drug Interactions Between Ritonavir-Boosted Nirmatrelvir (Paxlovid) and Concomitant Medications
The risk of interactions with omeprazole is greater than with other PPIs such as lansoprazole and pantoprazole
A total of 109 patients had a cardiovascular event, with event rates of 4
6), Drug Interactions (7)]
In summary an interaction between clopidogrel and PPIs seems to exist for omeprazole and esomeprazole, whereas there are only limited data for rabeprazole
Take omeprazole powder for oral suspension on an empty stomach at least 1 hour before a meal
Since a significant number of media reports came out in 2010 due to information regarding the omeprazole and clopidogrel interaction, it has been hotly debated as to how to manage this drug interaction