2009
2018
Thus, more rapid metabolism can result in lower, and possibly sub-therapeutic, levels of lamotrigine during pregnancy
Could taking lamotrigine cause other pregnancy complications? Lamotrigine has not been associated with an increased chance for other pregnancy complications, such as preterm delivery (birth before week 37) or poor growth of the baby (small size, low
Vajda FJ, et al
Estrogen increases the clearance of lamotrigine by inducing the liver enzymes involved in its
This study of lamotrigine exposure in early pregnancy more than doubled the size of the previous study population 13 (from 3
We identified deliveries by individuals aged 15 to 50 years between September 2018 and October 2021 using diagnosis and procedure codes (eTable in Supplement 1)
Clinicians should recommend their pregnant female patients to enroll in the North
12 Several small studies 13-15 of levetiracetam also suggest increased By 2018, the most prescribed ASM during pregnancy was lamotrigine, followed by pregabalin and gabapentin; valproate prescribing declined substantially
The treatment must balance the risk of seizures with the potential for adverse effects from drug use which may affect both the mother and developing fetus (Bech et al
Clearance of lamotrigine and levetiracetam doubles during pregnancy compared to before pregnancy
It is recommended that all women taking anti-epileptic medicines also take high dose folic acid (5mg/day) whilst trying to conceive and during the first Epub 2018 Jan 31
These amounts are usually small but sometimes it may pass into breast milk in larger amounts
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Lamotrigine is a prescription medication used to treat epilepsy and bipolar disorder
Quetiapine is found in low levels (less than 1% of the parent’s dose) in breast milk
Seizure 2018; 56:111–114Crossref, The use of combined oral contraceptive pills (OCPs) with lamotrigine has been shown to reduce lamotrigine concentrations by 50%, increasing the risk of seizures
Objective: To characterize the magnitude and course of alterations in total and free lamotrigine (LTG) clearance (Cl) during pregnancy and the postpartum period, to assess the impact of therapeutic drug monitoring (TDM) on seizure frequency, to determine the ratio to individual target LTG concentration that is associated with increased seizure
Method: This was a multicenter, double-blind, placebo-controlled randomized trial
Epub 2017 Jun 28
Epub 2018 Jan 31
For epilepsy, this includes focal seizures, tonic-clonic seizures, and seizures in Lennox-Gastaut syndrome
Lamotrigine oral tablets, chewable tablets, and ODT for epilepsy