In
Hydroxyurea, at a dose range between 25 to 30 mg/kg used for the treatment of SCD , reduces the frequency of painful crisis in SCD patients by increasing the levels of fetal hemoglobin, which has a higher oxygen carrying fertility in men with SCD, and the evi dence that hydroxyur ea therapy is associated wit h further decreasin g fertility in men with SCD
1 New data from a team of Italy-based investigators show association between spermatogenesis normalization and hydroxyurea discontinuation among Can hydroxyurea affect my fertility? Men • •Information is limited about men's fertility and using hydroxyurea
Hydroxyurea therapy, a chemotherapeutic agent, is the only US FDA approved therapy for the prevention of vaso-occlusive pain in sickle cell disease (SCD)
Figure 1
PURPOSE Hydroxyurea (HU) is a cytoreductive agent used as standard treatment option for sickle cell anaemia/disease (SCD), essential thrombocythemia (ET), and polycythaemia vera (PV)
Impairment of Fertility: Hydroxyurea administered to male rats at 60 mg/kg/day (about 0
x Recommendations for fertility management in adult men receiving Based on findings in animals and humans, male fertility may be compromised by treatment with hydroxyurea capsules
Two men in the post-HSCT group had a total sperm count >50 million compared to a maximum sperm count of only 2 million in the hydroxyurea group
Based on findings in animals and humans, male fertility may be compromised by treatment with hydroxyurea capsules
Azoospermia or oligospermia, sometimes reversible, has been observed in men
This study's primary objective was to analyze and compare sperm parameters in male patients with SCD exposed (or not) to HU before puberty
Azoospermia or oligospermia, sometimes reversible, has been observed in men
Azoospermia or oligospermia, sometimes reversible, has been observed in men
Acetaminophen was associated with reduced fertility and sperm quality in mice when given continuously at doses of 1
Focus is placed on hydroxyurea therapy given its benefits and increasing use in SCD
Adverse effect of hydroxyurea on spermatogenesis in patients with sickle cell anemia after 6 months of treatment The last unanswered question is related to the impact of HU on male fertility
However, it is important to use birth control because hydroxyurea may harm the baby if a pregnancy does occur
Transfusional iron overload and gonadal failure are addressed, followed by options for fertility preservation after stem cell Hence, the effects on male fertility due to hydroxyurea is not well studied in CML patients
Advances in diagnosing and treating SCD have allowed patients to reach reproductive age and live longer lives
Azoospermia or oligospermia, sometimes reversible, has been observed in men
Azoospermia or oligospermia, sometimes reversible, has been observed in men
do not have any vaccinations without 37, 38 There is mixed evidence regarding the impact of hydroxyurea treatment on fertility, with longer-term studies needed to clarify whether changes in sperm count or motility or hormonal markers The influence of hydroxyurea on fertility is complex, and cryopreservation appears to be a good method for mitigating any deleterious effects, as indicated by the birth of at least one infant in a recent study cohort after using cryopreserved semen
Hydroxycarbamide (hydroxyurea) may be genotoxic
It is also useful to increase fetal hemoglobin concentration, thus reducing the frequency of severe crisis and reducing the necessity for blood transfusions in patients with sickle cell anemia
How Does Chemotherapy Affect Male Fertility? Medically reviewed by Matt Coward, MD, FACS In males, the use of hydroxyurea has been associated with higher numbers of abnormal sperm, lower sperm count, and decreased fertility, 39 with one study finding higher rates of oligospermia and taking hydroxyurea
This review will systemically evaluate compromised fertility in men with SCD, and the
Hydroxyurea therapy contributes to infertility in adult men with sickle cell
Puberty Onset and Preservation of Fertility in Male Patients with Sickle
Key words: sickle cell disease, hydroxyurea, sperm, male fertility
1 New data from a team of Italy-based investigators show association between
Hydroxyurea use may damage spermatozoa and testicular tissue resulting in possible genetic abnormalities; males with female partners of reproductive potential should use effective contraception during and for at least 6 months (Siklos) or 1 year (Droxia, Hydrea) after therapy
If a male takes hydroxyurea, could it affect fertility or increase the chance of birth defects? There have been reports of lowered sperm count (number of sperm) and lowered sperm motility (movement of sperm) in males who take hydroxyurea
Introduction
Hydroxyurea therapy, a chemotherapeutic agent, is the only US FDA approved therapy for the prevention of vaso-occlusive pain in sickle cell
We, therefore, conducted a retrospective study to evaluate sperm parameters and fertility of men suffering from sickle cell disease; to analyze the potential impact of hydroxyurea and to consider the advisability 3
Azoospermia or oligospermia, sometimes reversible, has been observed in men
effects of hydroxyurea on male fertility has therefore become a question of public health
Pregnancy Men with SCA, regardless of hydroxyurea exposure, have numerous sperm and reproductive abnormalities that could decrease fertility [56-62]
Azoospermia or oligospermia, sometimes reversible, have been observed in men
Hydroxyurea is an antineoplastic agent used alone or in combination with other chemotherapeutic drugs or radiation in the treatment of resistant leukemias and carcinomas of the head and neck
3 times the maximum recommended human daily dose on