Lenalidomide and dexamethason

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  • Lenalidomide, a derivative of thalidomide, was approved by the U
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  • Lenalidomide plus dexamethasone is a standard treatment for patients with newly diagnosed multiple myeloma who are ineligible for autologous stem-cell transplantation

    Dexamethasone was given orally 40 mg daily on days 1 to 4, 9 to 12, and 17 to 20 of each cycle

    Each cycle may be repeated until the treatment no longer works or until unacceptable side effects occur

    Post-cycle 1 lenalidomide and dexamethasone dose modifications were specified in the protocol, as were minimum ANC and platelet levels prior to treatment on day 1 of each cycle

    Daratumumab plus lenalidomide and dexamethasone (D-Rd) versus lenalidomide and dexamethasone (Rd) in patients with newly Evidence-based recommendations on lenalidomide (Revlimid) plus dexamethasone for previously untreated multiple myeloma in adults

    Refer to Section 14

    Methods: In this phase 3 trial, we randomly assigned 569 patients with multiple myeloma who had received one or more previous lines of therapy to receive lenalidomide and dexamethasone either alone (control group Background: Lenalidomide is a cornerstone of maintenance therapy in patients with newly diagnosed multiple myeloma after autologous stem-cell transplantation

    The standard Rd regimen consisted of 25 mg oral lenalidomide once a day for days 1-21 plus 40 mg oral dexamethasone once a day on days 1, 8, 15, and 22

    In this phase 3 trial, we randomly assigned 498 patients with relapsed or relapsed and refractory multiple myeloma to receive bortezomib (1

    We chose ricolinostat 160 mg once daily on days 1-21 of a 28 day cycle as the recommended dose for future phase 2 studies in combination with lenalidomide 25 mg and dexamethasone 40 mg

    lenalidomide and dexamethasone in patients (pts) with previously untreated multiple myeloma without an intent Background: Minimal/measurable residual disease (MRD) post initial therapy is prognostic of long term outcomes in patients (pts) with newly diagnosed MM (NDMM), but has not been used to modify therapy

    The most common grade 3-4 adverse events were cytopenias, fatigue, muscle cramps, rash, infection, insomnia, and venous thromboe

    1 to 21

    We evaluated elotuzumab and weekly carfilzomib, lenalidomide, and dexamethasone (Elo-KRd) without ASCT in NDMM

    PATIENTS AND METHODS Patients were randomly Background: Bortezomib, lenalidomide, and dexamethasone (VRd) is a standard therapy for newly diagnosed multiple myeloma

    Bortezomib (Velcade), lenalidomide (Revlimid), and "low dose" dexamethasone (VRd) for multiple myeloma [1-3] Table 3

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    Dexamethasone: Dexamethasone is a steroid

    25 mg PO qDay on Days 1-21 of repeated 28-day cycles (use with dexamethasone) Ineligible for auto-HSCT: Continue until disease progression or unacceptable toxicity

    Patients with NDMM over the age of 65 and with an ECOG proxy frailty score ≥ 2 were randomized 1:2 to receive 28-day cycles of lenalidomide (25mg/day, 21/28) and dexamethasone (20mg QW) or daratumumab (1800mg SC QW for 8 weeks, Q2W for 16 weeks and Q4W thereafter), lenalidomide (25mg/day, 21/28) and 2 cycles of dexamethasone (20mg QW for 8 weeks), until progression or unacceptable Introduction: Daratumumab (DARA) is a human IgGκ monoclonal antibody targeting CD38 with a direct on-tumor and immunomodulatory mechanism of action

    Achieving and maintaining a high-quality response is the treatment goal for patients with newly diagnosed multiple myeloma (NDMM)

    Lenalidomide, bortezomib, and dexamethasone (RVD) regimen ( Table 1) has been studied in multiple myeloma as induction therapy regardless of transplantation eligibility

    Lenalidomide (CC-5013) is an analog of thalidomide that has demonstrated significantly more potent preclinical activity compared with thalidomide

    And it also stops cancers making their own blood vessels – cancers need a blood supply to be able to grow

    Successful treatment of scleromyxedema with daratumumab, lenalidomide and dexamethasone in a patient with multiple myeloma Australas J Dermatol

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