Separating the administration times of clopidogrel and omeprazole does not reduce this drug interaction
This attention reflects several factors, including the blockbuster status of the implicated drugs
Proton pump inhibitors (PPIs) are often used with clopidogrel to prevent gastrointestinal bleeding, however, some evidencemore
1, 2002, and
When information is available, interactions for boosted atazanavir (ATV) (with either ritonavir [RTV] or cobicistat
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Introduction: Patients with cardiovascular disease are commonly affected by a number of comorbidities leading to a high prevalence of polypharmacy
Clopidogrel needs metabolic activation Applies to: omeprazole and Plavix (clopidogrel) Talk to your doctor before using clopidogrel together with omeprazole
There is incontrovertible evidence from several randomized pharmacokinetic and pharmacodynamic studies that these 2 PPIs reduce Plavix active metabolite (AM) levels [by as much as 40% in some studies) and reduce the antiplatelet
Combining these medications may reduce the effectiveness of clopidogrel in preventing heart attack or stroke
For example, PPIs may affect the levels and potency of certain medications, such as clopidogrel (Plavix), warfarin (Coumadin), and some seizure and HIV medications, sometimes necessitating dosage adjustments of these drugs
I thought the inhibition of CYP 450 2C19 and 3A4 were a PPI class effect
It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent (dual antiplatelet therapy)
This column is an update to the April 2008 column that discussed the possible interaction between clopidogrel and proton pump inhibitors-new studies and data are brought into perspective