When should you seek medical care for alendronate side effects? Feb 1, 2024 · Stomach or bowel problems (eg, Barrett's esophagus, duodenitis, gastritis, heartburn, inflammation of the esophagus, or ulcers)—Use with caution
Jan 25, 2024 · Alendronate sodium, an aminobisphosphonate, is a selective inhibitor of osteoclast-mediated bone resorption
Fibrous dysplasia: Alendronate is used as an off-label medication for treating fibrous dysplasia of the bone
confusion convulsions cough diarrhea difficulty with breathing difficulty with moving heartburn heavy jaw feeling hives or welts irregular heartbeats itching Alendronate is a medication that treats osteoporosis
Alendronate is used to treat and prevent osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause
Drugs and Supplements Alendronate (Oral Route) Description and Brand Names Before Using Proper Use Precautions Side Effects Products and services Proper
While generally well tolerated, bisphosphonates can cause side effects such as nausea, dyspepsia, abdominal pain, muscle aches, and headaches
So, the reduced dosing frequency of MRS7216 due to the extremely long half-life of alendronate in bone, the potent inhibition of inflammation and osteoclast
Jaw pain
The client should report any eye pain or blurred vision to the provider
In a 3-year, controlled, clinical study (n = 2027) during which a majority of patients received concomitant NSAIDs, the incidence of upper gastrointestinal adverse events was similar in patients taking alendronate, the free acid
The anti-catabolic bisphosphonate alendronate is considered as the first-line medical treatment in post-menopausal osteoporosis; but several side effects, including gastric mucosal injury, are associated with its use
1% to 1%): Eye inflammation (uveitis, scleritis, episcleritis) Metabolic
In the current study, we fabricated tannic acid-alendronate (TA-ALN) nanocomplexes (NPXs) via self-assembly
Proper Use
Alendronate may make these conditions worse
strengthens bones by slowing the rate at which osteoclasts remove bone
Here, the case is reported of an orbital myositis triggered by alendronate
Dose‐related effects of dexamethasone on alendronate‐induced inflammatory reactions
Recommendations to reduce the risk of esophagitis include swallowing alendronate with 180 to 240 ml (6 to 8 oz) of water on arising in the morning, remaining upright for at least 30 minutes after swallowing the tablet and until the first These results suggest that alendronate may contribute to prevent adipocyte excessive enlargement and the induction of oxidative stress in 3T3-L1 adipocytes as well as the activation of macrophages to a pro-inflammatory M1 type, which are events associated with adipose tissue dysfunction and insulin resistance
Methods: We induced OA model by anterior cruciate ligament transection (ACLT) method in rats and treating chondrocytes
Ocular inflammation associated with alendronate therapy Arch Ophthalmol
However, in addition to having the pro-inflammatory properties of the nitrobisphosphonates, alendronate, at higher concentrations, has been shown to induce expression of inflammatory cytokines such as IL-8 in cultured human retinal pigment epithelial (RPE) cells which can be a potential pathway by which it can induce retinal
This drug may cause jawbone problems