Systemic toxicity, including neutropenia, stomatitis, and diarrhea, often occur due to cytotoxic nonselectivity
Lower-cost generic is available
5-fluorouracil (5-FU) and its oral formulation, capecitabine, are widely used in treating a range of malignancies, either alone or in combination with other antineoplastic drugs
Purpose: Capecitabine is a relatively new oral fluoropyrimidine currently licensed for the treatment of colorectal and breast cancer
IV fluorouracil and oral capecitabine share a lot of the same side effects
34 (95% CI 1
5: Start with 50% of the standard dose or avoid fluorouracil and capecitabine
They are used as a treatment for several different cancers, including: breast
Forms available from special-order manufacturers include Capecitabine (Xeloda), an oral fluoropyrimidine carbamate which is preferentially activated by thymidine phosphorylase in tumour cells, mimics continu
Capecitabine versus 5-fluorouracil/folinic acid as adjuvant therapy for stage III colon cancer: final results from the X-ACT trial with analysis by age Fluorouracil has been limited by poor oral absorption and gastrointestinal toxicity, despite of its vital importance in regimens for the treatment of rectal cancer, whereas capecitabine, which is a prodrug of 5-FU, can be orally administered; the final step of its conversion to the active form of 5-FU is performed by thymidine phosphorylase More specifically, we included fluorouracil or 5-FU or capecitabine and chest pain or angina and mechanism or treatment or management
5-fluorouracil (5-FU)/folinic acid (FA) as adjuvant therapy for stage III colon cancer
After oral administration of 1250 mg/m2, capecitabine is rapidly and extensively absorbe