The medical term medication-related osteonecrosis of the jaw s (MRONJ) defines a potentially severe condition that is a result of using specific medications, such as antiresorptive or antiangiogenic drugs
Medication-related osteonecrosis of the jaw (MRONJ) [1, 2], which includes bisphosphonate-related osteonecrosis of the jaw (BRONJ) , denosumab-related
Medication-related osteonecrosis of the jaw (MRONJ) is a refractory osteonecrosis caused by antiresorptive agents such as bisphosphonate and
Although rare, it can severely impair quality of life
swelling of the soft tissues and
Medication-related osteonecrosis of the jaw (MON, MRONJ) is progressive death of the jawbone in a person exposed to a medication known to increase the risk of disease, in
The American Association of Oral and Maxillofacial Surgeons (AAOMS) issued a revised
Medication-related osteonecrosis of the jaws (MRONJ) can be defined as “a drug-related adverse reaction, characterized by progressive bone
Despite the evolution of radiation treatment modalities, ORN continues to remain a therapeutic challenge and its etiopathogenesis still remains unclear
These antiresorptive drugs, which are designed to slow the loss of bone Osteonecrosis of the jaw is a complication that may occur in people with cancer receiving osteoporosis drugs or angiogenesis inhibitors
However, MRONJ is not limited to these 2 drug classes, and there are reports of other drugs being implicated in jaw necrosis
Medication-related osteonecrosis of the jaw (MRONJ) is a rare, severe debilitating condition from unknown causes
ONJ can be caused by two pharmacological agents: Antiresorptive (including bisphosphonates (BPs) and receptor activator of nuclear factor kappa-B ligand inhibitors Methotrexate-associated ONJ is serious clinical condition that may occur in patients with RA, but given the small number of cases we have found in the literature, direct involvement of methotrexate in the development of ONJ remains elusive
7% to 12%, mainly observed in those patients receiving intravenously treatment
Also called osteonecrosis, it can lead to tiny breaks in the bone and cause the bone to collapse
It may lead to surgical complication in the form of impaired wound healing following oral and maxillofacial surgery, periodontal surgery, or
The higher the bisphosphonate dose and the longer the exposure time, the more likely that osteonecrosis will develop
Patients and Methods ONJ was assessed prospectively since July
In Paget's disease and osteoporosis, where the doses of Osteonecrosis of the jaw (ONJ), also known as “dead jaw syndrome,” Avascular Necrosis and Aseptic Necrosis, is a rare but serious condition involving severe loss or destruction of the jawbone
Although MRONJ can be prevented by optimizing oral health, management of established cases is supportive and remains challenging